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Katrin Krumbholz - "Effect of coding or affecting coding? Mechanisms of stimulus-specific adaptation in human auditory cortex"

MRC Intitute of Hearing Research, University Park, Nottingham, UK

What
  • Organized in collaboration with MNI
When Dec 07, 2010
from 04:00 pm to 05:30 pm
Where Montreal Neurological Ins, De Grandpré Communications Centre, 3801 University Street
Contact Name
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ABSTRACT
Sensory neural responses depend strongly on the stimulus history, or context: The neural response to a sensory stimulus is temporarily suppressed when the stimulus is repeated and recovers when the stimulus is changed. This “stimulus-specific adaptation”, or “repetition suppression”, has become a popular tool for investigating representational mechanisms in visual cortex using functional magnetic resonance imaging (fMRI).

The current presentation is concerned with stimulus history, or context, effects in auditory cortical responses. In particular, it will be shown that, using EEG (electro-encephalography) rather than fMRI as measurement modality, and pairs of stimuli (one adapter and one probe stimulus), the stimulus specificity of adaptation in auditory cortex seems to reflect the specificity of single-neuron stimulus tuning. Moreover, when using longer, and more complex, stimulus sequences, context effects themselves seem to affect, or modify, neural tuning in auditory cortex. It will be argued that short-term context effects might represent a precursor to longer-term representational plasticity (perceptual learning). 


ABOUT KATRIN KRUMBHOLZ
I studied physics at Göttingen University in Germany, specialising in nuclear physics. I then went on to do my PhD on bat echolocation (using behavioural experiments) in Munich. From there, I moved to Roy Patterson’s lab in Cambridge, where I did psychoacoustic work on pitch perception and spatial hearing. Subsequently, I spent about two years at the Helmholtz Research Centre in Jülich, Germany, to learn fMRI and MEG. Now, I lead the Human Electrophysiology group at the MRC Institute of Hearing Research, Nottingham, UK. The group’s aim is to combine electroencephalography (EEG) with functional magnetic resonance imaging (fMRI) and psychophysical methods (psychoacoustics) to investigate the mechanisms by which acoustic information is transformed and represented in the human brainstem and auditory cortex.

 
   

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